https://www.dougepsteinlab.com/initiatives daily 0.75 2022-05-04 https://www.dougepsteinlab.com/initiatives/project-two-5mx4r monthly 0.5 2019-08-22 https://www.dougepsteinlab.com/initiatives/project-three-8m72z monthly 0.5 2019-08-22 https://www.dougepsteinlab.com/initiatives/project-one-3ytjn monthly 0.5 2019-08-22 https://www.dougepsteinlab.com/initiatives/project-four-4g93s monthly 0.5 2019-08-22 https://www.dougepsteinlab.com/publications daily 0.75 2022-12-07 https://www.dougepsteinlab.com/lab-members daily 0.75 2022-05-31 https://images.squarespace-cdn.com/content/v1/625d9fee3b8c11382d46c929/1651087587986-XZL6SC3GDAC2PYFZ67V0/IMG_6106.jpg Lab Members https://images.squarespace-cdn.com/content/v1/625d9fee3b8c11382d46c929/1651087720037-P6O9PZZ4KGQ64P41F69L/IMG_6096.jpg Lab Members https://images.squarespace-cdn.com/content/v1/625d9fee3b8c11382d46c929/1651160431891-12UWP0DQW0OL92RYQ5Q3/IMG_6128.jpg Lab Members https://images.squarespace-cdn.com/content/v1/625d9fee3b8c11382d46c929/1651687286457-CZ1XZKPTJJT8UYTBVXUO/IMG_6210.jpg Lab Members https://images.squarespace-cdn.com/content/v1/625d9fee3b8c11382d46c929/1651843517828-AN9KYLVJFABM0B8S7ZHG/IMG_6263.jpg Lab Members https://images.squarespace-cdn.com/content/v1/625d9fee3b8c11382d46c929/1654009317206-NBB6DKB1C0M46MXFZA2Q/1.jpg Lab Members https://www.dougepsteinlab.com/take-action daily 0.75 2022-04-18 https://www.dougepsteinlab.com/contact daily 0.75 2022-05-04 https://images.squarespace-cdn.com/content/v1/625d9fee3b8c11382d46c929/a773d324-8d59-4846-bd5b-d630e30aa9f1/philly-penn-skyline-quad.jpeg Contact https://www.dougepsteinlab.com/home daily 1.0 2022-05-30 https://images.squarespace-cdn.com/content/v1/625d9fee3b8c11382d46c929/fc871892-8de6-4239-9aeb-bea52efe96c8/Screen+Shot+2022-05-05+at+2.21.15+PM.jpg Home - How is Sonic hedgehog expression regulated during brain development? The Sonic hedgehog (Shh) gene is regulated by a well-characterized set of brain enhancers with essential roles in neurodevelopment. We use Shh enhancer knockout mouse models to: Study the mechanisms of enhancer redundancy and 3D folding dynamics of the locus in the developing brain Elucidate thalamic development and function Decipher neural circuits underlying abnormal motor and sensory information processing that occur in neurodevelopmental disorders https://images.squarespace-cdn.com/content/v1/625d9fee3b8c11382d46c929/8a1a30ee-be4a-4efa-9d5d-835bf81c0ac2/Figure1_IF__TC.jpg Home - What is the genetic basis of child and adult-onset hearing loss? Hearing loss is the most prevalent sensory deficit in humans. Approximately half of all cases of early onset hearing loss in developed countries have a genetic etiology, with single gene mutations in over 100 different loci identified so far. Despite this progress, the cause of inherited sensorineural hearing loss (SNHL) still remains uncertain in many cases. Remarkably, SNHL is even more common in adults, yet we know much less about the genetic architecture of hearing loss in the adult population. We interrogate the genetic basis of hearing loss: By leveraging whole exomes linked to electronic health records in the Penn Medicine Biobank As a multidisciplinary team with the Penn Center for Adult Onset Hearing Loss By generating mouse models of congenital and adult onset hearing loss; characterizing inner ear phenotypes; and designing novel treatment options https://www.dougepsteinlab.com/contact-us daily 0.75 2022-04-20 https://www.dougepsteinlab.com/apply daily 0.75 2022-05-30 https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1607694644871-IC85FNH781UNZSZEGHDR/Aro+Ha_0428.jpg Apply https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1607694583486-2PQT0LQ193RL7MCB6DX4/20140228_Trade+151_0046.jpg Apply https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1618497259178-6XJGK9GR6YAVBQL5L519/20140301_Trade-151_012-2.jpg Apply https://images.squarespace-cdn.com/content/v1/625d9fee3b8c11382d46c929/1651771482430-C0TLMNGF0CSSHJM813EF/maps.jpg Apply https://images.squarespace-cdn.com/content/v1/625d9fee3b8c11382d46c929/1651771873414-1W0QTN54KLFMANLFJVPB/hets.P0.Sox2.lif+-+1.jpg Apply https://images.squarespace-cdn.com/content/v1/625d9fee3b8c11382d46c929/1651772499862-W7V24620DXLD3UJC6IL1/Sixing-picture.jpg Apply https://images.squarespace-cdn.com/content/v1/625d9fee3b8c11382d46c929/1651774095152-3L4IY61IP634R5T9NWX0/Screen%2525252BShot%2525252B2022-05-05%2525252Bat%2525252B1.59.31%2525252BPM.jpg Apply https://images.squarespace-cdn.com/content/v1/625d9fee3b8c11382d46c929/1651774662585-I5V7JC8B29UK5K639MVD/Screen%252BShot%252B2022-05-05%252Bat%252B1.35.48%252BPM.jpg Apply https://www.dougepsteinlab.com/research daily 0.75 2022-05-30 https://images.squarespace-cdn.com/content/v1/625d9fee3b8c11382d46c929/22c179a3-01a3-47b9-a34c-ea63fffd4490/85.3+ctrl+slip20a+Shh+647+15%25+5%27+568+15%25+42mer+zli4+SW1398+SNW1398+point+cloud+300nm+mod.png Research - How do enhancers regulate Sonic hedgehog (Shh) expression during brain development? We focus on Shh enhancers that control unique and overlapping patterns of expression in the developing forebrain https://images.squarespace-cdn.com/content/v1/625d9fee3b8c11382d46c929/75031ebd-a461-4620-bfd9-01eeeca1dbab/Figure2_EM_Deiter%27s+cell.jpg Research - What is the genetic basis of adult-onset hearing loss? The identification of gene mutations associated with hearing loss in humans and animal models has contributed greatly to our understanding of cell type specific functions in the inner ear. Research in the Epstein lab is strongly motivated by the premise that a detailed elaboration of the molecular and cellular mechanisms of cochlear development and function will not only provide better insight into the workings of this complex sensory organ, but may also profoundly change the way inner ear disorders, including hearing loss, are treated in the future.